Binding and Uptake of Ligands by Scavenger Receptors
Sub-pathways within Pathway: Binding and Uptake of Ligands by Scavenger Receptors :
Binding and Uptake of Ligands by Scavenger Receptors:
Scavenger receptors bind free extracellular ligands as the initial step in clearance of the ligands from the body (reviewed in Ascenzi et al. 2005, Areschoug and Gordon 2009, Nielsen et al. 2010). Some scavenger receptors, such as the CD163-haptoglobin system, are specific for only one ligand. Others, such as the SCARA receptors (SR-A receptors) are less specific, binding several ligands which share a common property, such as polyanionic charges.
Brown and Goldstein originated the idea of receptors dedicated to scavenging aberrant molecules such as modified low density lipoprotein particles (Goldstein et al. 1979) and such receptors have been shown to participate in pathological processes such as atherosclerosis. Based on homology, scavenger receptors have been categorized into classes A-H (reviewed in Murphy et al. 2005).
Brown and Goldstein originated the idea of receptors dedicated to scavenging aberrant molecules such as modified low density lipoprotein particles (Goldstein et al. 1979) and such receptors have been shown to participate in pathological processes such as atherosclerosis. Based on homology, scavenger receptors have been categorized into classes A-H (reviewed in Murphy et al. 2005).
Vesicle-mediated transport:
The transit of proteins and other cargo through the cell requires a cellular transport process in which transported substances are moved in membrane-bounded vesicles. Transported substances are enclosed in the vesicle lumen or located in the vesicle membrane. The transport process begins with the formation of the vesicle itself, often triggered by the interaction of the cargo with the vesicle formation machinery. Vesicular transport pathways can include vesicle formation, coating, budding, uncoating and target membrane fusion depending upon the function of the pathway described. Vesicle-mediated transport occurs from within cell via ER and Golgi transport, as well as functioning in the endocytosis of material taken into the cell via scavenger receptors.