Pathway: IRF3-mediated induction of type I IFN
Reactions in pathway: IRF3-mediated induction of type I IFN :
IRF3-mediated induction of type I IFN
TANK-binding kinase 1 (TBK1) and interferon regulatory factor 3 (IRF3) are central regulators of type-I interferon induction during bacterial or viral infection. TBK1 was found to form complexes with distinct scaffolding proteins that appeared to target TBK1 to different subcellular compartments [Hemmi H et al 2004; Oganesyan G et al 2006; Chariot A et al 2002; Huang J et al 2005]. STING interacted with both TBK1 and IRF3. Once STING is stimulated, its C-terminus served as a signaling scaffold to recruit IRF3 anhd TBK1, which led to TBK1-dependent phosphorylation of IRF3. Phosphorylation of IRF3 promoted its dimerization and translocation to the nucleus, where it triggered the transcription of interferon stimulated genes (ISGs) (Tanaka Y and Chen ZJ 2012).
Innate immunity encompases the nonspecific part of immunity tha are part of an individual's natural biologic makeup
Humans are exposed to millions of potential pathogens daily, through contact, ingestion, and inhalation. Our ability to avoid infection depends on the adaptive immune system and during the first critical hours and days of exposure to a new pathogen, our innate immune system.