Reaction: Activation of GIRK/Kir3 Channels
Binding of G beta gamma activates the GIRK/Kir3 channels that allow the efflux of K+ out of the cell resulting in a hyperpolarized membrane potential. This negative membrane potential prevents the activation of voltage dependent Ca2+ channels.
Reaction - small molecule participants:
K+ [extracellular region]
K+ [cytosol]
K+ [extracellular region]
K+ [cytosol]
Reactome.org reaction link: R-HSA-1013020
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Reaction input - small molecules:
potassium(1+)
potassium(1+)
Reaction output - small molecules:
potassium(1+)
potassium(1+)
Reactome.org link: R-HSA-1013020