Reaction: NT5E:Zn2+ hydrolyses AMP,dAMP,GMP, IMP
- in pathway: Purine catabolism
5'-nucleotidase (NT5E) associated with the plasma membrane catalyzes the reactions of extracellular AMP, dAMP, GMP, or IMP with H2O to yield the corresponding nucleoside and orthophosphate. The active enzyme is a glycolipid-anchored dimer (Misumi et al. 1990; Thompson et al. 1987; Zimmerman 1992)
Reaction - small molecule participants:
Pi [extracellular region]
H2O [extracellular region]
Reactome.org reaction link: R-HSA-109278
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Reaction input - small molecules:
water
Reaction output - small molecules:
hydrogenphosphate
Reactome.org link: R-HSA-109278