Reaction: CMP or TMP or UMP + H2O => cytidine, thymidine, or uridine + orthophosphate [NT5E]
- in pathway: Pyrimidine catabolism
5'-nucleotidase (NT5E) associated with the plasma membrane catalyzes the reactions of extracellular CMP, TMP, or UMP with H2O to yield the corresponding nucleoside and orthophosphate. The active enzyme is a glycolipid-anchored dimer (Misumi et al. 1990; Thompson et al. 1987; Zimmerman 1992)
Reaction - small molecule participants:
Pi [extracellular region]
H2O [extracellular region]
Reactome.org reaction link: R-HSA-109291
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Reaction input - small molecules:
water
Reaction output - small molecules:
hydrogenphosphate
Reactome.org link: R-HSA-109291