Reaction: (d)GMP or (d)IMP + H2O => (d)G or (d)I + orthophosphate (NT5C)
- in pathway: Purine catabolism
Cytosolic 5'3'-nucleotidase (NT5C) catalyzes the hydrolysis of deoxy- and ribo- guanosine and inosine nucleoside monophosphates to yield the corresponding nucleosides and orthophosphate. The active form of the enzyme is a homodimer, with an absolute requirement for Mg++ (Hoglund and Reichard 1990; Rampazzo et al. 2000). This enzyme appears to play a central role in the "substrate cycles" that regulate cytosolic deoxynucleotide levels (Gazziola et al. 2001).
Reaction - small molecule participants:
Pi [cytosol]
H2O [cytosol]
Reactome.org reaction link: R-HSA-109470
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Reaction input - small molecules:
water
Reaction output - small molecules:
hydrogenphosphate
Reactome.org link: R-HSA-109470