Reaction: AKT2 binds PIP3
- in pathway: Activation of AKT2
The phosphorylation of membrane-recruited AKT at threonine and serine can be inhibited by direct binding of two different proteins, C-terminal modulator protein (THEM4 i.e. CTMP), which binds to the carboxy-terminal tail of AKT (Maira et al. 2001), or Tribbles homolog 3 (TRIB3), which binds to the catalytic domain of AKT (Du et al. 2003).
Reaction - small molecule participants:
PI(3,4,5)P3 [plasma membrane]
Reactome.org reaction link: R-HSA-109700
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Reaction input - small molecules:
1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate(7-)
Reaction output - small molecules:
Reactome.org link: R-HSA-109700