Reaction: Cleavage of uracil by UNG glycosylase
- in pathway: Cleavage of the damaged pyrimidine
UNG, a DNA uracil glycosylase, excises the uracil base generated when a DNA damaging agent deaminates cytosine (creating a U:G base pair) or when dUMP is misincorporated during DNA synthesis (creating a U:A base pair). UNG scans the DNA for damage by kinking and compressing the DNA phosphate backbone with a serine-proline pinch, which causes uracil to flip out at the phosphate-sugar junction into the recognition pocket of the UNG. The subsequent excision of uracil creates an apurinic/apyrimidinic (AP) site in the DNA (Parikh et al. 1998).
Reaction - small molecule participants:
Ura [nucleoplasm]
Reactome.org reaction link: R-HSA-110215
======
Reaction input - small molecules:
Reaction output - small molecules:
uracil
Reactome.org link: R-HSA-110215