Reaction: Cleavage of 5-hydroxyluracil by UNG glycosylase
- in pathway: Cleavage of the damaged pyrimidine
UNG, a DNA uracil glycosylase, cleaves 5-hydroxyuracil, generated by cytosine oxidation, from the DNA phosphate backbone, creating an apurinic/apyrimidinic (AP) site in the DNA (Dizdaroglu et al. 1996).
Reaction - small molecule participants:
5-OHU [nucleoplasm]
Reactome.org reaction link: R-HSA-110217
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Reaction input - small molecules:
Reaction output - small molecules:
5-hydroxyuracil
Reactome.org link: R-HSA-110217