Reaction: Cleavage of uracil by TDG glycosylase
- in pathway: Cleavage of the damaged pyrimidine
TDG is a G/T mismatch-specific thymine DNA glycosylase that cleaves uracil mispaired with guanine as a consequence of cytosine deamination, leaving an apurinic/apyrimidinic (AP) site in the DNA (Neddermann and Jiricny 1993, Hashimoto et al. 2012).
Reaction - small molecule participants:
Ura [nucleoplasm]
Reactome.org reaction link: R-HSA-110218
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Reaction input - small molecules:
Reaction output - small molecules:
uracil
Reactome.org link: R-HSA-110218