Reaction: Cleavage of thymine by TDG glycosylase
- in pathway: Cleavage of the damaged pyrimidine
TDG, a G/T mismatch-specific thymine DNA glycosylase, cleaves thymine, generated through 5-methylcytosine deamination and mispaired with guanine, from the DNA sugar-phosphate backbone, leaving an apurinic/apyrimidinic (AP) site (Neddermann and Jiricny 1993, Neddermann et al. 1996).
Reaction - small molecule participants:
Thy [nucleoplasm]
Reactome.org reaction link: R-HSA-110219
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Reaction input - small molecules:
Reaction output - small molecules:
thymine
Reactome.org link: R-HSA-110219