Reaction: Cleavage of uracil by SMUG1 glycosylase
- in pathway: Cleavage of the damaged pyrimidine
SMUG1 is a single-strand selective monofunctional uracil DNA glycosylase that cleaves uracil from the sugar phosphate backbone of DNA. SMUG1 has the highest preference for uracil in single strand DNA, followed by A:U and then G:U pairs in double strand DNA (Haushalter et al. 1999, Masaoka et al. 2003).
Reaction - small molecule participants:
Ura [nucleoplasm]
Reactome.org reaction link: R-HSA-110221
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Reaction input - small molecules:
Reaction output - small molecules:
uracil
Reactome.org link: R-HSA-110221