Reaction: Cleavage of thymine glycol by NTHL1 glycosylase
- in pathway: Cleavage of the damaged pyrimidine
NTHL1 (hNTH1; endonuclease III-like protein 1) cleaves oxidized thymine in the form of thymine glycol from DNA sugar-phosphate backbone and acts as a beta lyase to cleave the DNA sugar-phosphate backbone 5' to the apurinic/apyrimidinic (AP) site generated in the glycolysis step (Ikeda et al. 1998, Dizdaroglu et al. 1999, Miyabe et al. 2002).
Reaction - small molecule participants:
Tg [nucleoplasm]
Reactome.org reaction link: R-HSA-110224
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Reaction input - small molecules:
Reaction output - small molecules:
thymine glycol
Reactome.org link: R-HSA-110224