Reaction: Cleavage of cytosine glycol by NTHL1 glycosylase
- in pathway: Cleavage of the damaged pyrimidine
NTHL1 (hNTH1; endonuclease III-like protein 1) acts as a DNA glycosylase to cleave cytosine glycol (5,6-dihydroxycytosine), a product of cytosine oxidation, from the DNA sugar-phosphate backbone, creating an apurinic/apyrimidinic (AP) site (Dizdaroglu et al. 1999). After the AP site is created, NTHL1 can act as a beta lyase to cleave the DNA strand 5' to the AP site (Ikeda et al. 1998).
Reaction - small molecule participants:
Cg [nucleoplasm]
Reactome.org reaction link: R-HSA-110226
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Reaction input - small molecules:
Reaction output - small molecules:
cytosine glycol
Reactome.org link: R-HSA-110226