Reaction: Cleavage of dihydrouracil by NTHL1 glycosylase
- in pathway: Cleavage of the damaged pyrimidine
NTHL1 (hNTH1; endonuclease III-like protein 1) acts as a DNA glycosylase to cleave 5,6-dihydrouracil, formed by deamination of cytosine with partial saturation of the pyrimidine ring (Dizdaroglu et al. 1993), from the DNA sugar-phosphate backbone, and leaves an apurinic/apyrimidinic (AP) site. After the AP site is created, NTHL1 acts as a beta lyase to cleave the DNA strand 5' to the AP site (Ikeda et al. 1998).
Reaction - small molecule participants:
DHU [nucleoplasm]
Reactome.org reaction link: R-HSA-110227
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Reaction input - small molecules:
Reaction output - small molecules:
5,6-dihydrouracil
Reactome.org link: R-HSA-110227