Reaction: Cleavage of uracil by MBD4 glycosylase
- in pathway: Cleavage of the damaged pyrimidine
MBD4 (MED1; methyl-CpG-binding domain protein 4) cleaves uracil mispaired with guanine at non-methylated CpG islands, leaving an apurinic/apyrimidinic (AP) DNA site (Petronzelli et al. 2000).
Reaction - small molecule participants:
Ura [nucleoplasm]
Reactome.org reaction link: R-HSA-110231
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Reaction input - small molecules:
Reaction output - small molecules:
uracil
Reactome.org link: R-HSA-110231