Reaction: Cleavage of thymine by MBD4 glycosylase
- in pathway: Cleavage of the damaged pyrimidine
MBD4 (MED1; methyl-CpG-binding domain protein 4) cleaves thymine mispaired with guanine at CpG islands, which is a consequence of the oxidative deamination of 5-methylcytosine (Petronzelli et al. 2000). The MBD4 catalytic site is located at the C-terminus (Wu et al. 2003). MBD4 may be involved in the maintenance of genomic stability and active DNA demethylation.
Reaction - small molecule participants:
Thy [nucleoplasm]
Reactome.org reaction link: R-HSA-110232
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Reaction input - small molecules:
Reaction output - small molecules:
thymine
Reactome.org link: R-HSA-110232