Reaction: Excision of 8-oxoguanine by OGG1 glycosylase
- in pathway: Cleavage of the damaged purine
OGG1 acts as an N-glycosylase and a DNA beta-lyase to excise 8-oxoguanine (8oxoG) from dsDNA, creating an apurinic/apyrimidinic (AP) site, and to nick the DNA sugar-phosphate backbone 5' to the AP site, creating a single strand break (SSB) (Aburatani et al. 1997, Rosenquist et al. 1997, Roldan-Arjona et al. 1997, Radicella et al. 1997, Bjoras et al. 1997, Bruner et al. 2000).
Reaction - small molecule participants:
8oxoG [nucleoplasm]
Reactome.org reaction link: R-HSA-110243
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Reaction input - small molecules:
Reaction output - small molecules:
8-oxoguanine
Reactome.org link: R-HSA-110243