Reaction: Excision of FapyG by OGG1 glycosylase
- in pathway: Cleavage of the damaged pyrimidine
OGG1 acts as an N-glycosylase and a DNA beta-lyase to excise 2,6-diamino-4-hydroxy-5-formamidopyrimidine (FapyG), a one electron reduction product of guanine, from the DNA and to nickk the sugar-phosphate backbone 5' to the created apurinic/apyrimidinic (AP) site (Hu et al. 2005).
Reaction - small molecule participants:
FapyG [nucleoplasm]
Reactome.org reaction link: R-HSA-110244
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Reaction input - small molecules:
Reaction output - small molecules:
2,6-diamino-5-formamido-4-hydroxypyrimidine
Reactome.org link: R-HSA-110244