Reaction: REV1 inserts dCMP opposite to AP sites in DNA
- in pathway: Translesion synthesis by REV1
REV1 acts as a deoxycytidyl transferase to incorporate a single dCMP opposite a damaged DNA residue. REV1 most efficiently incorporates dCMP opposite apurinic/apyrimidinic (AP, abasic) sites. REV1 enables DNA damage bypass without repair of damaged DNA bases, but its low fidelity results in a mutagenic effect (Nelson et al. 1996, Lin et al. 1999, Gibbs et al. 2000, Zhang et al. 2002).
Reaction - small molecule participants:
dCTP [nucleoplasm]
Reactome.org reaction link: R-HSA-110308
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Reaction input - small molecules:
dCTP(4-)
Reaction output - small molecules:
Reactome.org link: R-HSA-110308