Reaction: IL6ST is tyrosine phosphorylated
- in pathway: Interleukin-6 signaling
Activated JAKs are believed to be responsible for phosphorylating the cytoplasmic region of IL6ST (gp130) (Wang & Fuller 1994, Reich & Liu 2006) creating docking sites for adaptor and downstream signaling molecules, in particular the factors STAT1 and STAT3. Several phosphotyrosine residues of IL6ST are docking sites for STATs (Stahl et al. 1995, Gerhartz et al. 1996), Tyr-759 phosphorylation allows recruitment of the phosphatase SHP2.
Reaction - small molecule participants:
ADP [cytosol]
ATP [cytosol]
Reactome.org reaction link: R-HSA-1112510
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Reaction input - small molecules:
ATP(4-)
Reaction output - small molecules:
ADP(3-)
Reactome.org link: R-HSA-1112510