Reaction: CaMK4 phosphorylates CREB1
- in pathway: CaMK IV-mediated phosphorylation of CREB
The cAMP-responsive element binding protein (CREB), a key regulator of gene expression, is activated by phosphorylation on Ser-133. Several different protein kinases possess the capability of driving this phosphorylation, making it a point of convergence for multiple intracellular signaling cascades. Work in neurons has indicated that physiologic synaptic stimulation recruits a fast calmodulin kinase IV (CaMKIV)-dependent pathway that dominates early signaling to CREB. Activated CaMKIV (CAMK4) phosphorylates CREB1 at S133, thereby initiating the transcription of CREB1-regulated set of genes, leading to protein synthesis and long lasting changes that underlie synaptic plasticity.
Reaction - small molecule participants:
ADP [nucleoplasm]
ATP [nucleoplasm]
ADP [nucleoplasm]
ATP [nucleoplasm]
ADP [nucleoplasm]
ATP [nucleoplasm]
Reactome.org reaction link: R-HSA-111912
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Reaction input - small molecules:
ATP(4-)
ATP(4-)
ATP(4-)
Reaction output - small molecules:
ADP(3-)
ADP(3-)
ADP(3-)
Reactome.org link: R-HSA-111912