Reaction: thymidine or deoxyuridine + orthophosphate <=> thymine or uracil + 2-deoxy-D-ribose 1-phosphate [TYMP]
- in pathway: Pyrimidine catabolism
Cytosolic thymidine phosphorylase (TYMP) catalyzes the reversible reactions of thymidine or deoxyuridine with orthophosphate to form thymine or uracil and 2-deoxy-D-ribose 1-phosphate. The active form of the enzyme is a homodimer (Desgranges et al. 1981; Norman et al. 2004; Usuki et al. 1992).
Reaction - small molecule participants:
dRibP [cytosol]
Pi [cytosol]
Reactome.org reaction link: R-HSA-112265
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Reaction input - small molecules:
hydrogenphosphate
Reaction output - small molecules:
2-deoxy-D-ribofuranose 1-phosphate(2-)
Reactome.org link: R-HSA-112265