Reaction: thymine or uracil + 2-deoxy-D-ribose 1-phosphate <=> thymidine or deoxyuridine + orthophosphate [TYMP]
- in pathway: Pyrimidine salvage
Cytosolic thymidine phosphorylase (TYMP) catalyzes the reversible reactions of thymine or uracil with 2-deoxy-D-ribose 1-phosphate to form thymidine or deoxyuridine and orthiophosphate. The active form of the enzyme is a homodimer (Desgranges et al. 1981; Norman et al. 2004; Usuki et al. 1992).
Reaction - small molecule participants:
Pi [cytosol]
dRibP [cytosol]
Reactome.org reaction link: R-HSA-112266
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Reaction input - small molecules:
2-deoxy-D-ribofuranose 1-phosphate(2-)
Reaction output - small molecules:
hydrogenphosphate
Reactome.org link: R-HSA-112266