Reaction: Formation of DSIF:NELF:early elongation complex
- in pathway: Formation of the Early Elongation Complex
NELF complex is a ~ 300 kDa multiprotein complex composed of 5 peptides (A - E): ~66,61,59,58 and 46 kDa. All these peptides are required for NELF-mediated inhibition of Pol II elongation. NELF complex has been reported to bind to the pre-formed DSIF:RNA Pol II complex that may act as a scaffold for its binding. NELF-A is suspected to be involved in Wolf-Hirschhorn syndrome.
Binding of DSIF:NELF to RNA Pol II CTD results in abortive termination of early elongation steps by the growing transcripts.
Binding of DSIF:NELF to RNA Pol II CTD results in abortive termination of early elongation steps by the growing transcripts.
Reaction - small molecule participants:
NTP [nucleoplasm]
NTP [nucleoplasm]
Reactome.org reaction link: R-HSA-113402
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Reaction input - small molecules:
nucleoside 5'-triphoshate(4-)
Reaction output - small molecules:
nucleoside 5'-triphoshate(4-)
Reactome.org link: R-HSA-113402