Reaction: Elongating transcript encounters a lesion in the template
- in pathway: RNA Polymerase II Pre-transcription Events
At the beginning of this reaction, 1 molecule of 'Processive elongation complex' is present. At the end of this reaction, 1 molecule of 'DSIF complex', 1 molecule of 'FACT complex', 1 molecule of 'RNA Polymerase II holoenzyme complex (hyperphosphorylated)', 1 molecule of 'damaged DNA substrate:nascent mRNA hybrid', 1 molecule of 'Elongin Complex', 1 molecule of 'FCP1P protein', 1 molecule of 'P-TEFb complex', 1 molecule of 'NELF complex', 1 molecule of 'RNA polymerase II elongation factor ELL', 1 molecule of 'NTP', 1 molecule of 'TFIIS protein', and 1 molecule of 'TFIIF' are present.
This reaction takes place in the 'nucleus' (Woudstra et al. 2002).
This reaction takes place in the 'nucleus' (Woudstra et al. 2002).
Reaction - small molecule participants:
NTP [nucleoplasm]
Reactome.org reaction link: R-HSA-113429
======
Reaction input - small molecules:
Reaction output - small molecules:
nucleoside 5'-triphoshate(4-)
Reactome.org link: R-HSA-113429