Reaction: PP2A mediated localization of RB1 protein in chromatin
Dephoshorylation of RB1 by the PP2A complex containing the regulatory subunit PPP2R3B (PR70) (Magenta et al. 2008) is needed for loading of RB1 to the DNA damage sites during S phase of the cell cycle. RB1 suppresses replication of damaged DNA during S phase (Knudsen et al. 2000, Avni et al. 2003).
Reaction - small molecule participants:
Pi [nucleoplasm]
H2O [nucleoplasm]
Reactome.org reaction link: R-HSA-113503
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Reaction input - small molecules:
water
Reaction output - small molecules:
hydrogenphosphate
Reactome.org link: R-HSA-113503