Reaction: Activation of conventional Protein Kinase C
- in pathway: Response to elevated platelet cytosolic Ca2+
Protein Kinase C (PKC) is positively regulated by events that increase the plasma membrane concentration of diacylglycerol (DAG). Activation of PKC requires the coordinated binding of two membrane-targeting domains. The C1 domain binds diacylglycerol, the C2 domain binds phosphatidylserine. Each can bind the membrane independently, but with insufficient affinity for membrane recruitment and activation.
Reaction - small molecule participants:
PS [plasma membrane]
DAG [plasma membrane]
Ca2+ [cytosol]
PS [plasma membrane]
DAG [plasma membrane]
Ca2+ [cytosol]
Reactome.org reaction link: R-HSA-114553
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Reaction input - small molecules:
3-sn-phosphatidyl-L-serine
1,2-diacyl-sn-glycerol
calcium(2+)
3-sn-phosphatidyl-L-serine
1,2-diacyl-sn-glycerol
calcium(2+)
Reaction output - small molecules:
Reactome.org link: R-HSA-114553