Reaction: PRKCB (Protein kinase C beta, PKC-beta) binds diacylglycerol and phosphatidylserine
- in pathway: Activation of NF-kappaB in B cells
Human Protein kinase C beta (PKC-beta) is activated by calcium ions, diacylglycerol, and binds phosphatidylserine (Kochs et al. 1991). Experiments in mice have shown that knocking out PKC-beta causes severe defects in B cells, leading to the conclusion that PKC-beta is the predominant signaling PKC in these cells (Leitges et al. 1996, Su et al. 2002, Saijo et al. 2002).
Reaction - small molecule participants:
PS [plasma membrane]
DAG [plasma membrane]
Ca2+ [cytosol]
Reactome.org reaction link: R-HSA-1168373
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Reaction input - small molecules:
3-sn-phosphatidyl-L-serine
1,2-diacyl-sn-glycerol
calcium(2+)
Reaction output - small molecules:
Reactome.org link: R-HSA-1168373