Reaction: STIM1 oligomerizes
In the resting state the luminal domain of STIM1 binds Ca2+ ions within the endoplasmic reticulum and this binding prevents dimerization of STIM1 (Luik et al. 2008). Upon depletion of Ca2+ ions from the endoplasmic reticulum, STIM1 is no longer bound to Ca2+ and forms homodimers (Muik et al. 2008, Luik et al. 2008, Park et al. 2009).
Reaction - small molecule participants:
Ca2+ [cytosol]
Reactome.org reaction link: R-HSA-1168376
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Reaction input - small molecules:
Reaction output - small molecules:
calcium(2+)
Reactome.org link: R-HSA-1168376