Reaction: ISGylation of host proteins
- in pathway: ISG15 antiviral mechanism
Many host proteins are targets for ISGylation including constitutively expressed proteins involved in various cellular pathways such as immunity, RNA splicing, chromatin remodeling/polymerase II transcription, stress responses and translation. Many ISG15 target proteins are IFN alpha/beta-induced antiviral proteins such as PKR, MxA, IRF3, and RIG-I, also included are several key regulators of signal transduction such as PLC gamma1, JAK1, STAT1 and ERK1. The contribution of most of these modified proteins to antiviral activity is unclear because the fate of the vast majority of ISGylated target proteins is unknown.
Reaction - small molecule participants:
PPi [cytosol]
AMP [cytosol]
ATP [cytosol]
Reactome.org reaction link: R-HSA-1169406
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Reaction input - small molecules:
ATP(4-)
Reaction output - small molecules:
diphosphate(3-)
adenosine 5'-monophosphate(2-)
Reactome.org link: R-HSA-1169406