Reaction: PADIs:Ca2+ deiminate L-Arg to L-Cit in proteins
- in pathway: Chromatin modifying enzymes
Methylation of histones by protein arginine methyltransferases (PRMTs), in general, is required for mammalian development and plays an important and dynamic role in gene regulation. Protein-arginine deiminases (PADIs) catalyse the deimination of L-arginine residues (L-Arg) in proteins to L-citrulline (L-Cit), thus playing a role in the regulation of development (Guerrin et al. 2003, Ishigami et al. 2002, Kanno et al. 2000, Wang et al. 2004, Nakayama-Hamada et al. 2005, Chavanas et al. 2004).
Reaction - small molecule participants:
NH3 [cytosol]
H2O [cytosol]
Reactome.org reaction link: R-HSA-1183128
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Reaction input - small molecules:
water
Reaction output - small molecules:
ammonia
Reactome.org link: R-HSA-1183128