Reaction: MscR reduces nitrosomycothiol to ammonia
- in pathway: Tolerance by Mtb to nitric oxide produced by macrophages
MscR is an alcohol dehydrogenase that can probably reduce nitrosomycothiol with the help of NADH/H+ reducing equivalents to the sulfinamide which then presumably decomposes to the thione and ammonia (Vogt et al. 2003).
Reaction - small molecule participants:
H2O [cytosol]
MSSM [cytosol]
NH3 [cytosol]
NAD+ [cytosol]
H+ [cytosol]
nitrosomycothiol [cytosol]
MSH [cytosol]
NADH [cytosol]
Reactome.org reaction link: R-HSA-1222583
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Reaction input - small molecules:
hydron
S-nitrosomycothiol
mycothiol
NADH(2-)
Reaction output - small molecules:
water
mycothione
ammonia
NAD(1-)
Reactome.org link: R-HSA-1222583