Reaction: Nitric oxide diffuses into the phagosome
- in pathway: ROS and RNS production in phagocytes
Nitric oxide diffuses into the phagosome (Clancy et al. 1994). Although NO has been shown to be critical for control of Mtb infection in mice, its role in human infection is less clear. Instead, the generation of antimicrobial defence molecules including cathelicidin in a vitamin D-dependent pathway is much better established (Fabri et al. 2011, Martineau et al. 2011).
Reaction - small molecule participants:
NO [phagocytic vesicle lumen]
NO [cytosol]
Reactome.org reaction link: R-HSA-1222686
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Reaction input - small molecules:
nitric oxide
Reaction output - small molecules:
nitric oxide
Reactome.org link: R-HSA-1222686