Reaction: Nitrosoglutathione gets cleaved to Cys(NO)-Gly
- in pathway: Tolerance by Mtb to nitric oxide produced by macrophages
Most gamma-glutamyl transpeptidases (GGT) cleave both glutathione and glutathione conjugates. Mtb GGT cleaves nitrosoglutathione )GSNO) to Cys(NO)-Gly, thus making it soluble for transport into the cytosol (Dayaram et al. 2006).
Reaction - small molecule participants:
S-NO-CysGly [periplasmic space]
γ-Glu-AA [periplasmic space]
GSNO [periplasmic space]
Reactome.org reaction link: R-HSA-1222712
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Reaction input - small molecules:
S-nitrosoglutathione
Reaction output - small molecules:
S-nitroso-L-cysteinylglycine
5-L-glutamyl amino acid
Reactome.org link: R-HSA-1222712