Reaction: Nitric oxide is oxidized to nitrate
- in pathway: Tolerance by Mtb to nitric oxide produced by macrophages
Heme proteins, especially the truncated globin GlbN in Mtb possess oxygen-dependent nitric oxide dioxygenase activity, where the heme that is oxidized to ferriheme in the process will need to be reduced in a second step to activate the protein again. The responsible heme protein reductase is unknown (Ouellet et al. 2002, Pathania et al. 2002).
Reaction - small molecule participants:
NO3- [cytosol]
NO+ [cytosol]
O2 [cytosol]
Reactome.org reaction link: R-HSA-1222723
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Reaction input - small molecules:
oxidonitrogen(1+)
dioxygen
Reaction output - small molecules:
nitrate
Reactome.org link: R-HSA-1222723