Reaction: Translocation of antigenic peptides back to phagosomes via TAP
- in pathway: ER-Phagosome pathway
After processing by the proteasome, some of the oligopeptides could be reinternalized to the phagosome lumen of the same phagosome through the TAP complex probably acquired during ER-phagosome fusion. Guermonprez et al. (2003) tested this model and observed abundant TAP complex in early phagosomes and its reduction over time. Electron microscopy analysis of purified phagosomes also showed the insertion of TAP2 into the phagosomal membrane.
Reaction - small molecule participants:
Pi [cytosol]
ADP [cytosol]
H2O [cytosol]
ATP [cytosol]
oligopeptide fragment (8-16aa) [cytosol]
Reactome.org reaction link: R-HSA-1236949
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Reaction input - small molecules:
water
ATP(4-)
oligopeptide
Reaction output - small molecules:
hydrogenphosphate
ADP(3-)
Reactome.org link: R-HSA-1236949