Reaction: Proteasomal clevage of exogenous antigen
Exogenous antigens are thought to be processed for cross-presentation in much the same manner as endogenous proteins once they enter the cytosolic pathway (Rock et al. 2010). Immunoproteasome components are the major proteases involved in generating the antigenic fragments. The precurssor peptides are further trimmed by cytosolic aminopeptidases and shuttled to ER through TAP for MHC class I loading.
Reaction - small molecule participants:
L-amino acid [cytosol]
precursor peptide fragment (>16 aa) [cytosol]
Exogenous soluble antigen [cytosol]
Reactome.org reaction link: R-HSA-1236970
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Reaction input - small molecules:
peptide
Reaction output - small molecules:
L-alpha-amino acid zwitterion
oligopeptide
Reactome.org link: R-HSA-1236970