Reaction: CA4:Zn2+ dehydrates HCO3- to CO2
- in pathway: Erythrocytes take up oxygen and release carbon dioxide
Carbonic anhydrase IV (CA4) located on the extracellular face of the plasma membrane (Wistrand et al. 1999) dehydrates bicarbonate (HCO3--) to yield water and carbon dioxide (CO2) (Zhu & Sly 1990, Okayuma et al. 1992, Baird et al. 1997, Innocenti et al. 2004, reviewed in Lindskog 1997). Depending on the concentrations of reactants the reaction is reversible.
Reaction - small molecule participants:
H2O [extracellular region]
CO2 [extracellular region]
H+ [extracellular region]
HCO3- [extracellular region]
Reactome.org reaction link: R-HSA-1237059
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Reaction input - small molecules:
hydron
hydrogencarbonate
Reaction output - small molecules:
water
carbon dioxide
Reactome.org link: R-HSA-1237059