Reaction: Acireductone is oxidized to MOB
- in pathway: Methionine salvage pathway
Acireducone (1,2-Dihydroxy-3-oxo-5'-methylthiopentene) is oxidized using acireductone dioxygenase and dioxygen. There are two reactions possible, dependent on the metal cofactor: the alternative product 3-methylthiopropionate using nickel was confirmed in Klebsiella. In eukaryotes using iron(II) the result is 4-methylthio-2-oxobutanoate (MOB). (Ju et al, 2006)
Reaction - small molecule participants:
HCOOH [cytosol]
4MTOBUTA [cytosol]
O2 [cytosol]
Acireductone [cytosol]
Reactome.org reaction link: R-HSA-1237119
======
Reaction input - small molecules:
dioxygen
1-hydroxy-5-(methylthio)-3-oxopent-1-en-2-olate
Reaction output - small molecules:
formate
4-methylthio-2-oxobutanoate
Reactome.org link: R-HSA-1237119