Reaction: SLC4A1 exchanges cytosolic Cl- for extracellular HCO3-
- in pathway: Erythrocytes take up oxygen and release carbon dioxide
The band 3 anion exchange protein (AE1, SLC4A1) exchanges chloride (Cl-) for bicarbonate (HCO3-) across the plasma membrane according to the concentration gradients of the anions (Knauf et al. 1996, Dahl et al. 2003). SLC4A1 may be part of a complex ("metabolon") with carbonic anhydrase II (CA2) which would facilitate the transport of HCO3- (Sterling et al. 2001).
Reaction - small molecule participants:
Cl- [extracellular region]
HCO3- [cytosol]
HCO3- [extracellular region]
Cl- [cytosol]
Reactome.org reaction link: R-HSA-1247665
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Reaction input - small molecules:
hydrogencarbonate
chloride
Reaction output - small molecules:
chloride
hydrogencarbonate
Reactome.org link: R-HSA-1247665