Reaction: GGCT transforms gGluCys to OPRO
- in pathway: Glutathione synthesis and recycling
Gamma-glutamylcyclotransferase (GGCT) homodimer (Bae et al. 2008) catalyses the formation of 5-oxoproline from gamma-glutamylcysteine (gGluCys), therby playing a role in glutathione homeostasis (Oakley et al. 2008).
Reaction - small molecule participants:
L-Cys [cytosol]
OPRO [cytosol]
gGluCys [cytosol]
Reactome.org reaction link: R-HSA-1247922
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Reaction input - small molecules:
L-gamma-glutamyl-L-cysteinate(1-)
Reaction output - small molecules:
L-cysteine zwitterion
5-oxo-L-prolinate
Reactome.org link: R-HSA-1247922