Reaction: Trans-autophosphorylation of ERBB2 homodimer
- in pathway: Constitutive Signaling by Overexpressed ERBB2
ERBB2 homodimers trans-autophosphorylate to form phosphorylated ERBB2 that activates downstream signaling cascades (Hazan et al. 1990, Ricci et al. 1995, Pickl and Ries 2009, Maadi et al. 2018). The best characterized trans-autophophosphorylation sites in ERBB2 heterodimers are tyrosines Y1023, Y1139, Y1196, Y1221, Y1222 and Y1248. Studies of ERBB2 homodimers have not investigated trans-autophosphorylated tyrosines of ERBB2 comprehensively. Instead, each study reported a subset of trans-autophosphorylation sites:
Y1023 and Y1248 (Hazan et al. 1990);
Y1139, Y1221 and Y1248 (Ricci et al. 1995);
Y1248 (Pickl and Ries 2009);
Y1139 and Y1248 (Maadi et al. 2018) – this study also identified Y1005, Y1112, Y1127 and Y1196 as trans-autophosphorylation sites.
For ERBB2 homodimers, six canonical sites (Y1023, Y1139, Y1196, Y1221, Y1222 and Y1248) have been annotated as trans-autophosphorylation sites. This information will be revised as more experimental data becomes available.
Y1023 and Y1248 (Hazan et al. 1990);
Y1139, Y1221 and Y1248 (Ricci et al. 1995);
Y1248 (Pickl and Ries 2009);
Y1139 and Y1248 (Maadi et al. 2018) – this study also identified Y1005, Y1112, Y1127 and Y1196 as trans-autophosphorylation sites.
For ERBB2 homodimers, six canonical sites (Y1023, Y1139, Y1196, Y1221, Y1222 and Y1248) have been annotated as trans-autophosphorylation sites. This information will be revised as more experimental data becomes available.
Reaction - small molecule participants:
ADP [cytosol]
ATP [cytosol]
Reactome.org reaction link: R-HSA-1248694
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Reaction input - small molecules:
ATP(4-)
Reaction output - small molecules:
ADP(3-)
Reactome.org link: R-HSA-1248694