Reaction: Activation of THIK
- in pathway: Tandem pore domain halothane-inhibited K+ channel (THIK)
THIK subfamily has 2 members, THIK1 and THIK 2. THIK 1 forms functional homodimers whereas THIK2 function has not been demonstrated. THIK1 channels are inhibited by halothane. THICK1 channels form K+ leak channels and are not regulated by acidity or alkalanity changes.
Reaction - small molecule participants:
K+ [extracellular region]
K+ [cytosol]
Reactome.org reaction link: R-HSA-1299297
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Reaction input - small molecules:
potassium(1+)
Reaction output - small molecules:
potassium(1+)
Reactome.org link: R-HSA-1299297