Reaction: MPP cleaves targeting peptide (presequence) of inner membrane precursors
- in pathway: Mitochondrial protein import
As inferred from yeast, the alpha subunit of the mitochondrial processing peptidase (MPP) binds presequences of mitochondrial precursors and the beta subunit cleaves the presequence. After cleavage, proteins destined for the inner membrane are released laterally from TIMM23 SORT into the membrane.
Reaction - small molecule participants:
H2O [mitochondrial matrix]
Reactome.org reaction link: R-HSA-1299476
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Reaction input - small molecules:
water
Reaction output - small molecules:
Reactome.org link: R-HSA-1299476