Reaction: MPP cleaves targeting peptide (presequence) of matrix precursors
- in pathway: Mitochondrial protein import
As inferred from yeast, the alpha subunit of the mitochondrial processing peptidase (MPP) binds presequences of mitochondrial precursors and the beta subunit cleaves the presequence. After cleavage, proteins destined for the matrix are drawn into the matrix by ATP-dependent interaction with mtHSP70 (HSPA9, homolog of yeast SSC1) of the PAM complex.
Reaction - small molecule participants:
H2O [mitochondrial matrix]
Reactome.org reaction link: R-HSA-1299478
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Reaction input - small molecules:
water
Reaction output - small molecules:
Reactome.org link: R-HSA-1299478