Reaction: Mitoferrin translocates iron from the mitochondrial intermembrane space to the mitochondrial matrix
- in pathway: Mitochondrial iron-sulfur cluster biogenesis
As inferred from biochemical studies in yeast and phenotypic studies in mouse, Mitoferrin-1 (SLC25A37) and Mitoferrin-2 (SLC25A28) transport ferrous iron across the inner mitochondrial membrane. Mitoferrin-1 is essential for maintaining mitochondrial iron uptake in developing erythroid cells; mitoferrin-2 is ubiquitously expressed. Defects in Mitoferrin-1 and Mitoferrin-2 cause a reduction in mitochondrial iron acquisition and biogenesis of iron-sulfur clusters and heme.
Reaction - small molecule participants:
Fe2+ [mitochondrial matrix]
Fe2+ [mitochondrial intermembrane space]
Reactome.org reaction link: R-HSA-1362417
======
Reaction input - small molecules:
iron(2+)
Reaction output - small molecules:
iron(2+)
Reactome.org link: R-HSA-1362417