Reaction: Dephosphorylation of p107 (RBL1) by PP2A
- in pathway: Cyclin D associated events in G1
Dephosphorylation of p107 (RBL1) by PP2A complex containing either PPP2R3B (B" beta) or PPP2R2A (B alpha) regulatory subunit plays a role in maintaining the equilibrium of hyperphosphorylated and hypophosphorylated p107 (RBL1), through counteracting action of cyclin dependent kinases (CDKs) throughout the cell cycle. It is assumed that PP2A dephosphorylates p107 (RBL1) on all four phosphorylation sites, but further experiments are needed to confirm this.
Reaction - small molecule participants:
Pi [nucleoplasm]
H2O [nucleoplasm]
Reactome.org reaction link: R-HSA-1363274
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Reaction input - small molecules:
water
Reaction output - small molecules:
hydrogenphosphate
Reactome.org link: R-HSA-1363274