Reaction: NR1D1 (REV-ERBA) binds heme, the ARNTL gene, and recruits corepressors.
- in pathway: Heme signaling
NR1D1 (REV-ERBA) binds heme. The NR1D1:heme complex is then able to recruit the corepressors NCoR and HDAC3. Corepressors do not bind NR1D1 in the absence of heme. NR1D1:heme binds a RRE element in the promoter of the ARNTL (BMAL1) gene, recruits corepressors, and represses transcription.
Reaction - small molecule participants:
ferriheme b [nucleoplasm]
ferriheme b [nucleoplasm]
Reactome.org reaction link: R-HSA-1368069
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Reaction input - small molecules:
ferriheme b
ferriheme b
Reaction output - small molecules:
Reactome.org link: R-HSA-1368069