Reaction: ABCAs mediate lipid influx
- in pathway: ABC transporters in lipid homeostasis
The exact roles of ABCA2 (Vulevic et al. 2001, Kaminski et al. 2001), ABCA6 (Kaminski & Wenzel et al. 2001), ABCA9 (Piehler et al. 2002) and ABCA10 (Wenzel et al. 2003), candidates for ABC lipid transporter-related activities, need to be elucidated. Even thought cholesterol-responsiveness has been noted in experimental systems, contribution of these proteins in regulation or in active transport is not yet clear.
Reaction - small molecule participants:
Pi [cytosol]
CHOL [cytosol]
ADP [cytosol]
CHOL [extracellular region]
H2O [cytosol]
ATP [cytosol]
Reactome.org reaction link: R-HSA-1369052
======
Reaction input - small molecules:
cholesterol
water
ATP(4-)
Reaction output - small molecules:
hydrogenphosphate
cholesterol
ADP(3-)
Reactome.org link: R-HSA-1369052